Tom Cech: New life beyond the RNA World
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Tom Cech: New life beyond the RNA World
To hear Tom Cech tell it, he came by his prodigious success — Nobel Prize at 41, presidency of the Howard Hughes Medical Institute (HHMI) this year at 52 — thanks to lots of help from his friends. His 1982 discovery that RNA could behave like an enzyme and splice itself led to the 1989 Nobel in chemistry, which he shared with Sidney Altman. But he says he stumbled into the RNA World — then a sm...
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In 1995, you could still find, in the opening paragraphs of manuscripts and grant applications from my lab and others, the phrase “In the absence of a crystal structure for the ribosome....,” by way of rationalizing any number of biochemical studies aimed at figuring out the three-dimensional locations of things inside the ribosome, and ultimately its mechanism. We no longer have this excuse. T...
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A simple multipoint procedure to test for parent-of-origin effects in samples of affected siblings is discussed. The procedure consists of artificially changing all full sibs to half-sibs, with distinct mothers or fathers depending on the parental origin to be evaluated, then analyzing these families with commonly used statistics and software. The procedure leads to tests for linkage through mo...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2000
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(00)00783-1